Progesterone in Pregnancy

What is Progesterone?

Progesterone is one of the dominant female hormones. It is essential during pregnancy. The corpus luteum, on the ovary, produces progesterone during the first trimester. After approximately 12 weeks, the placenta takes over this role. ​ —

Why would I need progesterone?

Women with a history of miscarriage, infertility, or luteal phase defect are at an increased risk of miscarriage. These women, in addition to women bleeding during pregnancy, may have low progesterone levels. The work of Dr. Thomas Hilgers at the Pope Paul VI Institute, among others, supports the use of progesterone supplementation to treat these conditions. The data has shown a decrease in pregnancy loss and complications when these low levels are treated with progesterone.

Is it safe?

The FDA has not approved progesterone therapy for women who are pregnant or trying to achieve pregnancy. This was due to complications related to the use of progestins, which are similar but not identical to progesterone. In fact, the American College of Obstetrics and Gynecology (ACOG) has officially recommended the FDA change this warning since the 1980’s. In addition, progesterone is the treatment of choice for preterm labor. In long-term studies there is no evidence that human identical progesterone is harmful in pregnancy.

How will I take it?

Intramuscular injections have been shown to have the most reliable absorption. Oral forms and vaginal suppositories are used in some patients.

Are there side-effects?

Common side-effects of the injections are localized redness, itching and pain. If you are experiencing any additional side effects or these are getting more intense, contact your provider. Patients with a peanut allergy should not take Prometrium brand of progesterone.

Will insurance cover these treatments?

Many insurances cover progesterone. You should check with your insurance company to find out what portion of the progesterone they will cover and what you will be responsible to cover. Important data to have when investigating this is: diagnosis for which you are being treated, whether you are covered for compounded drugs (the progesterone is formulated by a pharmacist), and whether you have better coverage for receiving the injections at the clinic or at home.

Why don't all doctors use progesterone supplementation in pregnancy?

The work of Dr. Hilgers has not been widely accepted among OB/GYN and Family Practice physicians. Yet, his research has been widely published and a growing number of physicians world-wide are following his protocols. Many of our patients come to our clinic specifically to receive these therapies. Most infertility patients who see an infertility specialist are treated with supplemental hormones, including progesterone and HCG to help decrease the risk of pregnancy loss.

Where can I research this treatment more thoroughly?

The protocols developed by Dr. Hilgers are called Naprotechnology. Certified Medical Consultants, like those practicing in our clinic, are trained in the use of these protocols. There is a description of the research and protocols available at: and

Clinic Hours / Appointments

Monday-Friday: 8am-5pm
Appointments: 651-653-0062

Urgent Care / After-Hours Care

We offer same day appointments during regular clinic hours for Urgent Care.

After-hours our doctors are on-call through our answering service: 651-653-0062